Saturday, December 18, 2010

Thyroid

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Thyroid gland or simply the thyroid  is one of the largest endocrine glands in the body, One of the most important glands in our body .  The thyroid gland is found in the neck, inferior to (below) the thyroid cartilage (also known as the Adam's Apple) and at approximately the same level as the cricoid cartilage. 
 It is shaped like a butterfly.
 
The thyroid controls how quickly the body uses energy, makes proteins, and controls how sensitive the body should be to other hormones.When it doesn't function properly, it can make you feel nervous or tired and you may experience muscular weakness.
Sudden weight gain or loss, dry skin patches, memory loss, and irregularities in your menstrual flow are all part of a thyroid disorder.
It can even cause miscarriage and infertility.

The thyroid gland participates in these processes by producing thyroid hormones, the principal ones being triiodothyronine (T3) and thyroxine (T4). These hormones regulate the rate of metabolism and affect the growth and rate of function of many other systems in the body. T3 and T4 are synthesized utilizing both iodine and tyrosine. 

The thyroid gland also produces calcitonin, which plays a role in calcium homeostasis.

The thyroid gland is controlled by the hypothalamus and pituitary . The thyroid gland gets its name from the Greek word for "shield", after the shape of the related thyroid cartilage. The most common problems of the thyroid gland consist of an over-active thyroid gland, referred to as 'hyperthyroidism', and an under-active thyroid gland, referred to as 'hypothyroidism'.

Hyperthyroidism

Hyperthyroidism, or overactive thyroid, is the overproduction of the thyroid hormones T3 and T4, and is most commonly caused by the development of Graves' disease, an autoimmune disease in which antibodies are produced which stimulate the thyroid to secrete excessive quantities of thyroid hormones. The disease can result in the formation of a toxic goiter as a result of thyroid growth in response to a lack of negative feedback mechanisms. It presents with symptoms such as a thyroid goitre, protruding eyes (exopthalmos), palpitations, excess sweating, diarrhea, weight loss, muscle weakness and unusual sensitivity to heat.

Hypothyroidism

Hypothyroidism is the underproduction of the thyroid hormones T3 and T4. Hypothyroid disorders may occur as a result of congenital thyroid abnormalities, autoimmune disorders such as Hashimoto's thyroiditis, iodine insufficiency, especially in poorer countries, or the removal of the thyroid following surgery to treat severe hyperthyroidism. Typical symptoms are abnormal weight gain, tiredness, baldness, temperature intolerance (both heat and cold), and palpitation. Individuals with thyroid gland underactivity may require hormone replacement therapy, which is typically required for the rest of the patient's life. Thyroid hormone treatment is given under the care of a physician and may take a few weeks to become effective.

Negative feedback mechanisms result in growth of the thyroid gland when thyroid hormones are being produced in sufficiently low quantities as a means of increasing the thyroid output; however, where the hypothyroidism is caused by iodine insufficiency, the thyroid is unable to produce T3 and T4 and as a result, the thyroid may continue to grow to form a non-toxic goiter. It is termed non-toxic as it does not produce toxic quantities of thyroid hormones, despite its size.

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